Chemical-Transporter Interaction Database

There are currently very few resources which provide a comprehensive view of how chemicals interact with transporter proteins. Chemical effects on transporter function are of critical interest in pharmacology and the effects of unintentional exposures to chemicals on transporters is a growing topic of interest. Most collections of transporter-chemical interaction data focus on human transporters specifically in the context of pharmacy and drug development. In 2022 our lab collaborated with researchers at UCSF and UCSD to update the UCSF-FDA Transportal to more than triple its content of interaction data to assist researchers. 

The Nicklisch Lab aims to bring additional attention to the potential effects of transporter-chemical interactions on human, agricultural and environmental health in the context of environmental exposures that humans and other organisms receive. We continue to be actively involved in compiling data scattered from across the literature into accessible and understandable data sources for researchers, medical personnel and the public alike. We are particularly interested in kinetic, gene expression and drug-drug interaction data and the information that metanalysis of the literature can reveal about transporter function. Additionally, a high-level view of the field allows us to fill the gaps in transporter exploration, especially involving organisms highly impacted by humans, including honey bees, aquatic species and plant crops.